Misinformation shared on social media has a serious impact,” Kardashian West wrote in a statement on Tuesday.
The move is part of the #StopHateforProfit campaign which was organised by civil rights activists.
The celebrities will freeze their accounts for 24 hours on Wednesday.
“I can’t sit by and stay silent while these platforms continue to allow the spreading of hate, propaganda and misinformation – created by groups to sow division and split America apart,” Kardashian West said.
Other celebrities that have agreed to take part in the boycott include actors Leonardo DiCaprio, Sacha Baron Cohen and Jennifer Lawrence, as well as singer Katy Perry.
In June, Facebook said it would label potentially harmful or misleading posts left up for their news value.
Founder Mark Zuckerberg also said the social media company would ban advertising containing claims “that people of a specific race, ethnicity, national origin, religious affiliation, caste, sexual orientation, gender identity or immigration status” are a threat to others.